Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner

作者：Yuchen Wang, Yan Cao, Cassandra L. Hays, Thibaut Laboute, Thomas A. Ray, Debbie Guerrero‐Given, Abhimanyu S. Ahuja, Dipak N. Patil, Olga Rivero, Naomi Kamasawa, Jeremy N. Kay, Wallace B. Thoreson, Kirill A. Martemyanov · 发表于：Proceedings of the National Academy of Sciences · 年份：2021 · DOI：10.1073/pnas.2106694118 · 被引用次数：17 · 研究领域：Neurobiology and Insect Physiology Research、Receptor Mechanisms and Signaling、Retinal Development and Disorders

Significance This study addresses a fundamental question in neuroscience: how do neurons functionally specify and diversify their synaptic connections? This question is particularly relevant in the visual system in which neurons handle a broad range of stimuli requiring synapses to adjust their gain accordingly. In this work, we describe how synapses of cone photoreceptors, which all vertebrate animals utilize for daylight vision, handle this task through an elegant trans-synaptic mechanism involving a splice isoform of a cell-adhesion molecule, Latrophillin 3.