Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics

作者：Piao Zhou, Wei Shi, Xiao-Yan He, Quanyu Du, Fei Wang, Jing Guo · 发表于：Pharmaceutical Biology · 年份：2021 · DOI：10.1080/13880209.2021.1992448 · 被引用次数：90 · 研究领域：Natural product bioactivities and synthesis、Bioactive Compounds and Antitumor Agents、Natural Compounds in Disease Treatment

Context Bupleuri Radix, the dried root of Bupleurum chinense DC and Bupleurum scorzonerifolium Willd (Apiaceae), is an important medicinal herb widely used to treat cancers for hundreds of years in Asian countries. As the most antitumour component but also the main toxic component in Bupleuri Radix, saikosaponin D (SSD) has attracted extensive attention. However, no summary studies have been reported on the antitumour effects, toxicity and pharmacokinetics of this potential natural anticancer substance.Objective To analyse and summarise the existing findings regarding to the antitumour effects, toxicity and pharmacokinetics of SSD.Materials and methods We collected relevant information published before April 2021 by conducting a search of literature available in various online databases including PubMed, Science Direct, CNKI, Wanfang database and the Chinese Biological Medicine Database. Bupleurum, Bupleuri Radix, saikosaponin, saikosaponin D, tumour, toxicity, and pharmacokinetics were used as the keywords.Results The antitumour effects of SSD were multi-targeted and can be realised through various mechanisms, including inhibition of proliferation, invasion, metastasis and angiogenesis, as well as induction of cell apoptosis, autophagy, and differentiation. The toxicological effects of SSD mainly included hepatotoxicity, neurotoxicity, haemolysis and cardiotoxicity. Pharmacokinetic studies demonstrated that SSD had the potential to alter the pharmacokinetics of some drugs fo...