MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration

作者：Scarlett J. Barker, Ravikiran M. Raju, Noah Milman, Jun Wang, José Dávila-Velderrain, Fatima Gunter‐Rahman, Cameron Parro, P. Lorenzo Bozzelli, Fatema Abdurrob, Karim Abdelaal, David A. Bennett, Manolis Kellis, Li‐Huei Tsai · 发表于：Science Translational Medicine · 年份：2021 · DOI：10.1126/scitranslmed.abd7695 · 被引用次数：101 · 研究领域：Genetics and Neurodevelopmental Disorders、Neurogenesis and neuroplasticity mechanisms、Mitochondrial Function and Pathology

in the PS19 mouse model of tauopathy and found that this was sufficient to improve cognitive flexibility and reduce hyperexcitability. Overall, our findings reveal a previously unappreciated role for MEF2 TFs in promoting CgR, highlighting their potential as biomarkers or therapeutic targets for neurodegeneration and healthy aging.