Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against septic AKI

作者：Ni Yin, Bangchuan Hu, Guohua Wu, Ziqiang Shao, Yang Zheng, Run Zhang, Jun Jin, Jun Hong, Xianghong Yang, Ren-Hua Sun, Jinquan Liu, Shi‐Jing Mo · 发表于：Theranostics · 年份：2021 · DOI：10.7150/thno.61902 · 被引用次数：38 · 研究领域：Neutrophil, Myeloperoxidase and Oxidative Mechanisms、S100 Proteins and Annexins、Sepsis Diagnosis and Treatment

Our preclinical data propose that interrupting NETs formation in combination with Fn14 mAb might be a feasible therapeutic strategy for septic AKI.