Alterations in Effective Connectivity of the Hippocampus in Migraine without Aura

作者：Yadi Zhu, Lingling Dai, Hongru Zhao, Boan Ji, Yang Yu, Hui Dai, Chunhong Hu, Ximing Wang, Jun Ke · 发表于：Journal of Pain Research · 年份：2021 · DOI：10.2147/jpr.s327945 · 被引用次数：46 · 研究领域：Migraine and Headache Studies、Traumatic Brain Injury Research、Functional Brain Connectivity Studies

PURPOSE: Neuroimaging studies on migraine have revealed structural and functional alterations in the hippocampus, a region involved in pain processing and stress response. This study was designed to investigate whether effective connectivity of this region is disrupted in migraine and relates to chronicity of this disease. PATIENTS AND METHODS: In 39 episodic migraine (EM) patients, 17 chronic migraine (CM) patients, and 35 healthy controls, we investigated differences in the directional influences between the hippocampus and the rest of the brain by combining resting-state functional magnetic resonance imaging and Granger causality analysis (GCA), with bilateral hippocampus as seed regions. The associations between directional influences and the clinical variables were also examined. RESULTS: Comparing each patient group to the control group, we found increased and decreased negative influence on the hippocampus exerted by the bilateral visual areas and right dorsolateral prefrontal cortex (dlPFC), respectively. The hippocampus showed increased positive influence on the right posterior insula and medial prefrontal cortex (mPFC), as well as increased negative influence on the left cerebellum in CM patients relative to EM patients and healthy controls. Furthermore, across all patients, the migraine frequency exhibited a positive and negative association with causal influence from the hippocampus to mPFC and left cerebellum, respectively. CONCLUSION: Migraine patients have abno...