Connectivity-Based Topographical Changes of the Corpus Callosum During Aging

作者：Yuchen Liu, Chih‐Chin Heather Hsu, Chu‐Chung Huang, Yajuan Zhang, Jiajia Zhao, Shih‐Jen Tsai, Liang‐Kung Chen, Ching‐Po Lin, Chun‐Yi Zac Lo · 发表于：Frontiers in Aging Neuroscience · 年份：2021 · DOI：10.3389/fnagi.2021.753236 · 被引用次数：19 · 研究领域：Advanced Neuroimaging Techniques and Applications、Functional Brain Connectivity Studies、Advanced MRI Techniques and Applications

Background: The corpus callosum (CC) is the most prominent white matter connection for interhemispheric information transfer. It is implicated in a variety of cognitive functions, which tend to decline with age. The region-specific projections of the fiber bundles with microstructural heterogeneity of the CC are associated with cognitive functions and diseases. However, how the CC is associated with the information transfer within functional networks and the connectivity changes during aging remain unclear. Studying the CC topography helps to understand the functional specialization and age-related changes of CC subregions. Methods: Diffusion tractography was used to subdivide the CC into seven subregions from 1,086 healthy volunteers within a wide age range (21–90 years), based on the connections to the cortical parcellations of the functional networks. Quantitative diffusion indices and connection probability were calculated to study the microstructure differences and age-related changes in the CC subregions. Results: According to the population-based probabilistic topography of the CC, part of the default mode network (DMN) and limbic network (LN) projected fibers through the genu and rostrum; the frontoparietal network (FPN), ventral attention network (VA) and somatomotor networks (SM) were interconnected by the CC body; callosal fibers arising from the part of the default mode network (DMN), dorsal attention network (DA) and visual network (VIS) passed through the spleni...