Pathogenicity of the MAGE family (Review)

作者：Sanyan Li, Xiang Shi, Jingping Li, Xianrong Zhou · 发表于：Oncology Letters · 年份：2021 · DOI：10.3892/ol.2021.13105 · 被引用次数：28 · 研究领域：Immunotherapy and Immune Responses、Ubiquitin and proteasome pathways、Glycosylation and Glycoproteins Research

The melanoma antigen gene (MAGE) protein family is a group of highly conserved proteins that share a common homology domain. Under normal circumstances, numerous MAGE proteins are only expressed in reproduction-related tissues; however, abnormal expression levels are observed in a variety of tumor tissues. The MAGE family consists of type I and II proteins, several of which are cancer-testis antigens that are highly expressed in cancer and serve a critical role in tumorigenesis. Therefore, this review will use the relationship between MAGEs and tumors as a starting point, focusing on the latest developments regarding the function of MAGEs as oncogenes, and preliminarily reveal their possible mechanisms.