The interaction of lipids and inflammatory markers predict negative symptom severity in patients with schizophrenia

作者：David R. Goldsmith, Nicholas Massa, Brian J. Miller, Andrew H. Miller, Erica Duncan · 发表于：Schizophrenia · 年份：2021 · DOI：10.1038/s41537-021-00179-8 · 被引用次数：18 · 研究领域：Tryptophan and brain disorders、Schizophrenia research and treatment、Stress Responses and Cortisol

Finding biological predictors and novel mechanisms underlying negative symptoms of schizophrenia is of significant importance given the lack of effective treatments. Increasing data support a role for metabolic dysfunction and inflammation in reward processing deficits in psychiatric illness. Herein, we found an interaction between lipids and inflammation as a predictor of worse negative symptom severity in individuals with schizophrenia. Future studies may seek to further elucidate this relationship and thereby reveal novel treatment targets for negative symptoms.