2D Piezoelectric Bi 2 MoO 6 Nanoribbons for GSH‐Enhanced Sonodynamic Therapy

作者：Yushan Dong, Shuming Dong, Bin Liu, Chenghao Yu, Jing Liu, Dan Yang, Piaoping Yang, Jun Lin · 发表于：Advanced Materials · 年份：2021 · DOI：10.1002/adma.202106838 · 被引用次数：334 · 研究领域：Nanoplatforms for cancer theranostics、Luminescence Properties of Advanced Materials、Perovskite Materials and Applications

Abstract Reducing the scavenging capacity of reactive oxygen species (ROS) and elevating ROS production are two primary goals of developing novel sonosensitizers for sonodynamic therapy (SDT). Hence, ultrathin 2D Bi 2 MoO 6 –poly(ethylene glycol) nanoribbons (BMO NRs) are designed as piezoelectric sonosensitizers for glutathione (GSH)‐enhanced SDT. In cancer cells, BMO NRs can consume endogenous GSH to disrupt redox homeostasis, and the GSH‐activated BMO NRs (GBMO) exhibit an oxygen‐deficient structure, which can promote the separation of electron–hole pairs, thereby enhancing the efficiency of ROS production in SDT. The ultrathin GBMO NRs are piezoelectric, in which ultrasonic waves introduce mechanical strain to the nanoribbons, resulting in piezoelectric polarization and band tilting, thus accelerating toxic ROS production. The as‐synthesized BMO NRs enable excellent computed tomography imaging of tumors and significant tumor suppression in vitro and in vivo. A piezoelectric Bi 2 MoO 6 sonosensitizer‐mediated two‐step enhancement SDT process, which is activated by endogenous GSH and amplified by exogenous ultrasound, is proposed. This process not only provides new options for improving SDT but also broadens the application of 2D piezoelectric materials as sonosensitizers in SDT.