The emerging roles of neutrophil extracellular traps in wound healing

作者：Shuainan Zhu, Ying Yu, Yun Ren, Liying Xu, Huilin Wang, Xiaomin Ling, Lin Jin, Yanmin Hu, Hao Zhang, Changhong Miao, Kefang Guo · 发表于：Cell Death and Disease · 年份：2021 · DOI：10.1038/s41419-021-04294-3 · 被引用次数：181 · 研究领域：Neutrophil, Myeloperoxidase and Oxidative Mechanisms、S100 Proteins and Annexins、Cell Adhesion Molecules Research

Delayed wound healing causes problems for many patients both physically and psychologically, contributing to pain, economic burden, loss of function, and even amputation. Although many factors affect the wound healing process, abnormally prolonged or augmented inflammation in the wound site is a common cause of poor wound healing. Excessive neutrophil extracellular trap (NET) formation during this phase may amplify inflammation and hinder wound healing. However, the roles of NETs in wound healing are still unclear. Herein, we briefly introduce NET formation and discuss the possible NET-related mechanisms in wound healing. We conclude with a discussion of current studies, focusing on the roles of NETs in diabetic and normoglycemic wounds and the effectiveness of NET-targeting treatments in wound healing.