A Low-Producing Haplotype of Interleukin-6 Disrupting CTCF Binding Is Protective against Severe COVID-19

作者：Tao Chen, Yuxin Lin, Yan Zha, Ying Sun, Jinxiu Tian, Zhiying Yang, Shanwen Lin, Fuxun Yu, Zi‐Sheng Chen, Bo‐Hua Kuang, Jin-Ju Lei, Yingjie Nie, Yonghao Xu, Dongbo Tian, Yingzi Li, Bin Yang, Qiang Xu, Li Yang, Nanshan Zhong, Meizhen Zheng, Yimin Li, Jincun Zhao, Xiangyan Zhang, Lin Feng · 发表于：mBio · 年份：2021 · DOI：10.1128/mbio.01372-21 · 被引用次数：45 · 研究领域：Inflammasome and immune disorders、interferon and immune responses、COVID-19 Clinical Research Studies

Overproduction of cytokine interleukin-6 (IL-6) is a hallmark of severe COVID-19 and is believed to play a critical role in exacerbating the excessive inflammatory response. Polymorphisms in IL-6 account for the variability of IL-6 expression and disparities in infectious diseases, but its contribution to the clinical presentation of COVID-19 has not been reported.