Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial

作者：Stefano Del Prato, Steven E. Kahn, Imre J. Pavo, Govinda J. Weerakkody, Zhengyu Yang, John Doupis, Diego Aizenberg, Alan G Wynne, Jeffrey S. Riesmeyer, Robert J. Heine, Russell J. Wiese, Andrew Ahmann, Samir Arora, Eric M. Ball, Rafael Burgos-Calderón, David Butuk, Leila Chaychi, Michael C. Chen, Brian M. Curtis, Ronald H. Chochinov, Christopher Chow, Clancy Cone, Lisa E. Connery, Gregorio Cortes-Maisonet, José de Souza, Kathleen Marie Dungan, David P. Bradley, Juan P. Frías, Nashwa Gabra, Linda Gaudiani, Luis Herandez-Vazquez, Stanley H. Hsia, Michael Jardula, ERIC J. KLEIN, Mark E Kutner, Juan Loy, Francisco G Miranda, Lazaro Nunez, Miguel Mujica-Baella, Alexander V. Murray, Michael J Oliver, Ramon Oritz-Carrasquillo, Betsy Palal, Michael T Parke, Athena Philis‐Tsimikas, Raman Purighalla, Julio Rosenstock, Airani Sathananthan, Courtney Shelton, Kanagaratnam Sivalingam, Ehab Sorial, Joseph Soufer, Helen L. Stacey, Larry D. Stonesifer, Stanley Stringam, Joanna T Van, Jose B. Vazquez-Tanus, Ramón López de los Reyes, Michelle Welch, Najmuddin Karimjee, Earl E Martin, Ahmed A. Arif, Timothy W Jennings, Neil James Fraser, Anuj Bhargava, Alan G Wynne, Evelyne Davidson, Liana K. Billings, Elizabeth A Barranco-Santana, Michael E. Dever, Patrick T. Walsh, A.K. Cho, James W. Chu, Jay H. Shubrook, Albert B. Knouse, Venkatesh Nadar, Lorena Lewy-Alterbaum, Michael J. Lillestol, Daniel J Humiston, Alexander J. White, Ronald K. Mayfield, Fahed Bitar, Fernando Cereto, Carmen de la Cuesta, L. de Teresa Parreño, Esteban Jódar Gimeno, Pedro Mezquita‐Raya, Cristóbal Morales, Miguel Quesada Charneco, Francisco José Tinahones, Santiago Tofé, Luis Alberto Vázquez, Carmen Fajardo, Alfonso González, Cristina V. Mistodie, Iosif Szilagyi, Adriana Filimon, Nicoleta Mihaela Mîndrescu, Lavinia Pop, Marlena Pascu, Gabriela Negrişanu, Daniela Ciomos, Valentina Neacşu, Amalia Thury-Burileanu, Idit F. Liberty, Naftali Stern, Yael Sofer, Jessica Sack, Ilan Shimon, Amir Tirosh, Avraham Ishay, Ofri Mosenzon Ninio, Naim Shehadeh, Julio Wainstein, Mahmud Darawsha, Dasa Skripova, Eva Pavleova, Viera Doničová, Ludmila Kubincova, Dalibor Sosovec, Martina Merciakova, Fadia El Boreky, Eric St-Amour, Zeina Yared, François Blouin, Buki Ajala, Naresh Aggarwal, HARPREET SINGH BAJAJ, Chetna Tailor, Alan Egan, John O’Mahony, Natasha St.Onge, James R. W. Conway, Gustavo Akerman Augusto, João Lindolfo Cunha Borges, Maria Cerqueira, Denise Reis Franco, Tatiana Franco Hirakawa, Filipe Dias de Souza, Miguel Nasser Hissa, Luciana Muniz Pechmann, Camila P Calil Salim, Luis Augusto Tavares Russo, Joselita Siqueira, Sonia Angelica Sassone, Jorge Archibaldo Glenny, Martín Koretzky, Diego Aizenberg, Andrea Steinacher, Silvana E Solis, Lucrecia Nardone, Federico C. Pérez Manghi, Silvia Ines Orio, Elizabeth Gelersztein, Jose Osvaldo Fretes, Pedro Calella, Cesar Javier Zaidman, Alejandro Chertkoff, Susana Salzberg, Claudio R. Majul, Luis A Nevarez, R. Ortiz, Ramiro G. Banda Elizondo, R. Villicana, Guillermo González-Gálvez, C. Calvo, Andrzej Kościański, Henryk Rudzki, Andrzej Stankiewicz, Dariusz Sowiński, Ewa Krzyżagórska, Małgorzata Józefowska, Beata Matyjaszek‐Matuszek, Edward Franek, Ewa Skokowska, Anna Modzelewska, Ewa Szyprowska, Richard W Simpson, Christopher P. Gilfillan, David Martin Colquhoun, Timothy M. E. Davis, Claire Morbey, Shannon E McCarthy, Kamal Kaur, Lauren Kemp, Antony J Shea, Yuriy Sh Khalimov, Olga A Miroshnichenko, Irina Vladimirovna Dvoryashina, Irina Al'bertovna Karpova, М. А. Куницына, Наталья Владимировна Ворохобина, Gagik Radikovich Galstyan, Ирина Аркадьевна Бондарь, Evgeniy V Filippov, О. Б. Ершова, Horng‐Yih Ou, Shih-Ting Tseng, Jung‐Fu Chen, Kai‐Jen Tien, Chien‐Ning Huang, Ching‐Chu Chen, Chii‐Min Hwu, Te‐Lin Hsia, John Doupis, Emmanouil M. Pagkalos, Zadalla Mouslech, Αlexandra Bargiota, Kalliopi Kotsa · 发表于：The Lancet · 年份：2021 · DOI：10.1016/s0140-6736(21)02188-7 · 被引用次数：669 · 研究领域：Diabetes Treatment and Management、Bariatric Surgery and Outcomes、Hyperglycemia and glycemic control in critically ill and hospitalized patients