Palladium-Catalyzed Three-Component Cascade Reaction of Nitriles: Synthesis of 2-Arylquinoline-4-carboxylates

作者：Zhiwei Zhao, Zeng Ge, Yinan Chen, Jinming Zheng, Zhongyan Chen, Yinlin Shao, Fangjun Zhang, Jiuxi Chen, Renhao Li · 发表于：Organic Letters · 年份：2021 · DOI：10.1021/acs.orglett.1c02962 · 被引用次数：13 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Biological Evaluation、Radical Photochemical Reactions

A new method for converting easy availability starting materials 2-(2-oxoindolin-3-yl)acetonitrile, arylboronic acids, and alcohols into 2-arylquinoline-4-carboxylates is reported. The procedure involves a three-component addition/ring expansion/esterification reaction in the presence of Pd(II) catalyst with high functional group tolerance under mild conditions. In addition, the photophysical properties of the resulting product were investigated and exhibited excellent polarity-sensitive fluorescence properties and AIE property.