Total and regional fat‐to‐muscle mass ratio measured by bioelectrical impedance and risk of incident type 2 diabetes

作者：Ningjian Wang, Ying B Sun, Haojie Zhang, Chi Chen, Yuying Wang, Jihui Zhang, Fangzhen Xia, Christian Benedict, Xiao Tan, Yingli Lu · 发表于：Journal of Cachexia Sarcopenia and Muscle · 年份：2021 · DOI：10.1002/jcsm.12822 · 被引用次数：67 · 研究领域：Body Composition Measurement Techniques、Diabetes, Cardiovascular Risks, and Lipoproteins、Nutrition and Health in Aging

Abstract Background The fat‐to‐muscle mass ratio (FMR) might be an indicator to assess type 2 diabetes risk independent of general obesity. However, no longitudinal studies have explored the extent to which total and regional FMRs may confer risks. We aimed to measure the sex‐specific associations between FMRs of the arm, leg, trunk and whole body and incident type 2 diabetes. Methods A total of 464 817 participants (207 286 men and 257 531 women, mean age 56.5 ± 8.2 and 56.2 ± 8.0 years old, respectively) free of diabetes at baseline were included in this prospective cohort study with UK Biobank data. Fat mass and muscle mass were estimated using a bioelectrical impedance assessment device (Tanita BC 418MA). FMR was calculated as fat mass divided by muscle mass in corresponding body parts (total body, arm, leg and trunk). Cox proportional hazard models were used to estimate the aforementioned associations among men and women. Interaction analyses were performed between FMRs and body mass index (BMI) categories (BMI < 25 kg/m 2 and BMI ≥ 25 kg/m 2 ). Results Over the median 11.0 years (5 057 534 person‐years) of follow‐up, we documented 11 618 cases of type 2 diabetes. There was a significantly positive association between total and regional FMR and incident type 2 diabetes, even after adjusting for BMI and other covariates. Compared with other body parts, FMRs of the whole body and leg showed the strongest relationship among men and women, respectively (hazard ratio per 1 SD...