Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development

作者：Reem Aljanabi, Lina Alsous, Dima A. Sabbah, Halise Inci Gul, Mustafa K. Gul, Sanaa K. Bardaweel · 发表于：Molecules · 年份：2021 · DOI：10.3390/molecules26196019 · 被引用次数：80 · 研究领域：Click Chemistry and Applications、14-3-3 protein interactions、Protein Degradation and Inhibitors

Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through oxidative deamination. Owing to the crucial role of MAOs in maintaining functional levels of neurotransmitters, the implications of its distorted activity have been associated with numerous neurological diseases. Recently, an unanticipated role of MAOs in tumor progression and metastasis has been reported. The chemical inhibition of MAOs might be a valuable therapeutic approach for cancer treatment. In this review, we reported computational approaches exploited in the design and development of selective MAO inhibitors accompanied by their biological activities. Additionally, we generated a pharmacophore model for MAO-A active inhibitors to identify the structural motifs to invoke an activity.