Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl 4 : roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-β1/Smad axis

作者：Guangwen Shu, Arslan Yusuf, Chenxi Dai, Hui Sun, Xukun Deng · 发表于：Food & Function · 年份：2021 · DOI：10.1039/d1fo02657g · 被引用次数：54 · 研究领域：Liver physiology and pathology、Liver Disease Diagnosis and Treatment、Drug Transport and Resistance Mechanisms

. PIP modulated the intrahepatic contents of the markers of EMT and HSC activation. In mouse livers, PIP activated Nrf2 signaling and reduced Smad2/3-dependent gene transcriptions. Our findings collectively suggested PIP as a new chemical entity with the capacity of alleviating liver fibrosis. The activation of the Nrf2 cascade and subsequent suppression of the TGF-β1/Smad axis are implicated in the hepatoprotective activity of PIP.