Glucose Detection Devices and Methods Based on Metal–Organic Frameworks and Related Materials

作者：Muhammad Adeel, Kanwal Asif, Md. Mahbubur Rahman, Salvatore Daniele, Vincenzo Canzonieri, Flavio Rizzolio · 发表于：Advanced Functional Materials · 年份：2021 · DOI：10.1002/adfm.202106023 · 被引用次数：182 · 研究领域：Electrochemical sensors and biosensors、Advanced Nanomaterials in Catalysis、Advanced biosensing and bioanalysis techniques

Abstract Assessment of glucose concentration is important in the diagnosis and treatment of diabetes. Since the introduction of enzymatic glucose biosensors, scientific and technological advances in nanomaterials have led to the development of new generations of glucose sensors. This field has witnessed major developments over the last decade, as the novel nanomaterials are capable of efficiently catalyzing glucose directly (i.e., act as artificial enzymes, therefore defined nanozymes) or to entrap enzymes that are able to oxidize glucose. Among other nanomaterials, metal–organic frameworks (MOFs) have recently provided a tremendous basis to construct glucose sensing devices. MOFs are large porous crystalline compounds with versatile structural and tuneable chemical properties. In addition, they possess catalytic, peroxidase‐like, and electrochemical redox activity. This review comprehensively summarizes the general characteristics of MOFs, their subtypes, and MOF composites, as well as MOF‐derived materials employed to construct electrochemical, optical, transistor, and microfluidic devices for the detection of glucose. They include enzymatic, nonenzymatic, wearable, and flexible sensing devices and methods. The review also outlines the design and synthesis of MOFs and the working principles of the different transduction‐based glucose sensors and highlights the current challenges and future perspectives.