Humoral immune responses to COVID-19 vaccination in people living with HIV receiving suppressive antiretroviral therapy

作者：Zabrina L. Brumme, Francis Mwimanzi, Hope R. Lapointe, Peter K. Cheung, Yurou Sang, Maggie C. Duncan, Fatima Yaseen, Olga Agafitei, Siobhan Ennis, Kurtis Ng, Simran Basra, Li Yi Lim, Rebecca Kalikawe, Sarah Speckmaier, Nadia Moran-Garcia, Landon Young, Hesham Ali, Bruce Ganase, Gisele Umviligihozo, F. Harrison Omondi, Kieran Atkinson, Hanwei Sudderuddin, Junine Toy, Paul Sereda, Laura Burns, Cecilia T. Costiniuk, Curtis Cooper, Aslam H. Anis, Victor C. M. Leung, Daniel T. Holmes, Mari L. DeMarco, Janet Simons, Malcolm Hedgcock, Marc G. Romney, Rolando Barrios, Silvia Guillemi, Chanson J. Brumme, Ralph Pantophlet, Julio Montaner, Masahiro Niikura, Marianne Harris, Mark Hull, Mark A. Brockman · 发表于：medRxiv · 年份：2021 · DOI：10.1101/2021.10.03.21264320 · 被引用次数：23 · 研究领域：SARS-CoV-2 and COVID-19 Research、COVID-19 Clinical Research Studies、COVID-19 Impact on Reproduction

ABSTRACT Humoral responses to COVID-19 vaccines in people living with HIV (PLWH) remain incompletely understood. We measured circulating antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein, ACE2 displacement and live viral neutralization activities one month following the first and second COVID-19 vaccine doses in 100 adult PLWH and 152 controls. All PLWH were receiving suppressive antiretroviral therapy, with median CD4+ T-cell counts of 710 (IQR 525-935) cells/mm 3 . Nadir CD4+ T-cell counts ranged as low as <10 (median 280; IQR 120-490) cells/mm 3 . After adjustment for sociodemographic, health and vaccine-related variables, HIV infection was significantly associated with 0.2 log 10 lower anti-RBD antibody concentrations (p=0.03) and ∼11% lower ACE2 displacement activity (p=0.02), but not lower viral neutralization (p=0.1) after one vaccine dose. Following two doses however, HIV was no longer significantly associated with the magnitude of any response measured. Rather, older age, a higher burden of chronic health conditions, and having received two ChAdOx1 doses (versus a heterologous or dual mRNA vaccine regimen) were independently associated with lower responses. After two vaccine doses, no significant correlation was observed between the most recent or nadir CD4+ T-cell counts and vaccine responses in PLWH. These results suggest that PLWH with well-controlled viral loads on antiretroviral therapy and CD4+ T-cell counts in a healthy ra...