Total Lung and Lobar Quantitative Assessment Based on Paired Inspiratory–Expiratory Chest CT in Healthy Adults: Correlation with Pulmonary Ventilatory Function

作者：Feihong Wu, Leqing Chen, Jia Huang, Wenliang Fan, Jinrong Yang, Xiaohui Zhang, Yang Jin, Fan Yang, Chuansheng Zheng · 发表于：Diagnostics · 年份：2021 · DOI：10.3390/diagnostics11101791 · 被引用次数：13 · 研究领域：Respiratory Support and Mechanisms、Chronic Obstructive Pulmonary Disease (COPD) Research、Inhalation and Respiratory Drug Delivery

Objective: To provide the quantitative volumetric data of the total lung and lobes in inspiration and expiration from healthy adults, and to explore the value of paired inspiratory–expiratory chest CT scan in pulmonary ventilatory function and further explore the influence of each lobe on ventilation. Methods: A total of 65 adults (29 males and 36 females) with normal clinical pulmonary function test (PFT) and paired inspiratory–expiratory chest CT scan were retrospectively enrolled. The inspiratory and expiratory volumetric indexes of the total lung (TL) and 5 lobes (left upper lobe [LUL], left lower lobe [LLL], right upper lobe [RUL], right middle lobe [RML], and right lower lobe [RLL]) were obtained by Philips IntelliSpace Portal image postprocessing workstation, including inspiratory lung volume (LVin), expiratory lung volume (LVex), volume change (∆LV), and well-aerated lung volume (WAL, lung tissue with CT threshold between −950 and −750 HU in inspiratory scan). Spearman correlation analysis was used to explore the correlation between CT quantitative indexes of the total lung and ventilatory function indexes (including total lung capacity [TLC], residual volume [RV], and force vital capacity [FVC]). Multiple stepwise regression analysis was used to explore the influence of each lobe on ventilation. Results: At end-inspiratory phase, the LVin-TL was 4664.6 (4282.7, 5916.2) mL, the WALTL was 4173 (3639.6, 5250.9) mL; both showed excellent correlation with TLC (LVin-TL: r ...