Site-Selective Photosynthesis of Ag–AgCl@Au Nanomushrooms for NIR-II Light-Driven O 2 - and O 2 •– -Evolving Synergistic Photothermal Therapy against Deep Hypoxic Tumors

作者：Sha Liu, Jian Chai, Shihao Sun, Lang Zhang, Jiayue Yang, Fu Xu, Jun Hai, Yuhong Jing, Baodui Wang · 发表于：ACS Applied Materials & Interfaces · 年份：2021 · DOI：10.1021/acsami.1c16999 · 被引用次数：22 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Advanced Photocatalysis Techniques

Light-driven endogenous water oxidation has been considered as an attractive and desirable way to obtain O 2 and reactive oxygen species (ROS) in the hypoxic tumor microenvironment. However, the use of a second near-infrared (NIR-II) light to achieve endogenous H 2 O oxidation to alleviate tumor hypoxia and realize deep hypoxic tumor phototherapy is still a challenge. Herein, novel plasmonic Ag–AgCl@Au core–shell nanomushrooms (NMs) were synthesized by the selective photodeposition of plasmonic Au at the bulge sites of the Ag–AgCl nanocubes (NCs) under visible light irradiation. Upon NIR-II light irradiation, the resulting Ag–AgCl@Au NMs could oxidize endogenous H 2 O to produce O 2 to alleviate tumor hypoxia. Almost synchronously, O 2 could react with electrons on the conduction band of the AgCl core to generate superoxide radicals (O 2 •– )for photodynamic therapy. Moreover, Ag–AgCl@Au NMs with an excellent photothermal performance could further promote the phototherapy effect. In vitro and in vivo experimental results show that the resulting Ag–AgCl@Au NMs could significantly improve tumor hypoxia and enhance phototherapy against a hypoxic tumor. The present study provides a new strategy to design H 2 O-activatable, O 2 - and ROS-evolving NIR II light-response nanoagents for the highly efficient and synergistic treatment of deep O 2 -deprived tumor tissue.