Caregiver burden by treatment and clinical characteristics of patients with glioblastoma

作者：Trang H. Au, Connor Willis, Maija Reblin, Katherine B. Peters, Phioanh L. Nghiemphu, Jennie Taylor, Howard Colman, Adam L. Cohen, D. Ryan Ormond, Arnab Chakravarti, Nicole E. Willmarth, Jyothi U. Menon, Junjie Ma, Hillevi Bauer, Alexandre H. Watanabe, Cornelia M. Ulrich, Prianka Singh, Alexander Marshall, Beata Korytowsky, David D. Stenehjem, Diana Brixner · 发表于：Supportive Care in Cancer · 年份：2021 · DOI：10.1007/s00520-021-06514-0 · 被引用次数：32 · 研究领域：Cancer survivorship and care、Cancer-related cognitive impairment studies、Dementia and Cognitive Impairment Research

BACKGROUND: Glioblastoma is an incurable disease with a poor prognosis. For caregivers of people with glioblastoma, the burden of care can be high. Patients often present with different clinical characteristics, which may impact caregiver burden in different ways. This study aimed to evaluate associations between patient clinical characteristics and caregiver burden/quality of life (QoL). METHODS: Caregiver-patient dyads were enrolled at 7 academic cancer centers in the United States. Eligible caregiver participants were self-reported as the primary caregiver of an adult living with glioblastoma and completed a caregiver burden survey. Eligible patients were age ≥ 18 years at glioblastoma diagnosis and alive when their respective caregiver entered the study, with the presence of cognitive dysfunction confirmed by the caregiver. Data were analyzed with descriptive statistics and multivariable analyses. RESULTS: The final cohort included 167 dyads. Poor patient performance status resulted in patient difficulty with mental tasks, more caregiving tasks, and increased caregiving time. Language problems were reported in patients with left-sided lesions. Patient confusion was negatively associated with all caregiver domains: emotional health, social health, general health, ability to work, confidence in finances, and overall QoL. Better caregiver QoL was observed in patients with frontal lobe lesions versus non-frontal lobe lesions. CONCLUSION: This study reinforced that patient per...