Acupuncture for Quality of Life in Gastric Cancer Patients Undergoing Adjuvant Chemotherapy

作者：Yan-juan Zhu, Xiaoyu Wu, Wei Wang, Xuesong Chang, Dandan Zhan, Dechang Diao, Jian Xiao, Yong Li, Dong Ma, Ming Hu, Jianchang Li, Jin Wan, Guannan Wu, Chuanfeng Ke, Kaiyu Sun, Zhiliang Huang, Taiyuan Cao, Xiaohui Zhai, Yadong Chen, Jianjun Peng, Jun J. Mao, Haibo Zhang · 发表于：Journal of Pain and Symptom Management · 年份：2021 · DOI：10.1016/j.jpainsymman.2021.09.009 · 被引用次数：42 · 研究领域：Acupuncture Treatment Research Studies、Cancer survivorship and care、Nausea and vomiting management

CONTEXT: Patients with gastric cancer experience health-related quality of life (HRQOL) decline during adjuvant chemotherapy following gastrectomy. OBJECTIVES: This pilot study aimed to evaluate the preliminary effect and feasibility of electro-acupuncture (EA) for HRQOL and symptom burden in these patients. METHODS: In this open-label, multicenter, parallel controlled trial, gastric cancer patients who planned to receive adjuvant chemotherapy were randomly assigned to receive high-dose EA (seven times each chemotherapy cycle for three cycles), low-dose EA (three times each chemotherapy cycle), or usual care only. The acupoints prescription consisted of bilateral ST36, PC6, SP4, and DU20, EX-HN3, and selected Back-shu points. Patients completed the Functional Assessment of Cancer Therapy-Gastric (FACT-Ga) weekly, and the Edmonton Symptom Assessment System (ESAS). The primary outcome was the difference among the groups on the gastric cancer subscale (GaCS) of the FACT-Ga. RESULTS: Of the 66 randomized patients, 58 were analyzed according to intention-to-treat principle, and 45 were in the per-protocol set (PPS). The average scores in PPS of GaCS were 52.12±9.71, 51.85±12.36, and 45.37±8.61 in high-dose EA, low-dose EA, and control groups, respectively. EA was significantly associated with improved average GaCS scores when compared with control group (51.98±10.91 vs. 45.37±8.61, P = 0.039). EA treatment also produced ESAS relief at the end of intervention (14.36 ± 12.28 vs. 23....