Intrinsic capacity and its associations with incident dependence and mortality in 10/66 Dementia Research Group studies in Latin America, India, and China: A population-based cohort study

作者：Martin Prince, Daisy Acosta, Mariella Guerra, Yueqin Huang, K. S. Jacob, Ivonne Z. Jiménez‐Velázquez, Jotheeswaran Amuthavalli Thiyagarajan, Juan J. Llibre Rodríguez, Aquiles Salas, Ana Luisa Sosa, Isaac Acosta, Rosie Mayston, Zhaorui Liu, Jorge J. Llibre‐Guerra, Matthew Prina, Adolfo Valhuerdi · 发表于：PLoS Medicine · 年份：2021 · DOI：10.1371/journal.pmed.1003097 · 被引用次数：137 · 研究领域：Dementia and Cognitive Impairment Research、Geriatric Care and Nursing Homes、Frailty in Older Adults

BACKGROUND: The World Health Organization (WHO) has reframed health and healthcare for older people around achieving the goal of healthy ageing. The recent WHO Integrated Care for Older People (ICOPE) guidelines focus on maintaining intrinsic capacity, i.e., addressing declines in neuromusculoskeletal, vitality, sensory, cognitive, psychological, and continence domains, aiming to prevent or delay the onset of dependence. The target group with 1 or more declines in intrinsic capacity (DICs) is broad, and implementation may be challenging in less-resourced settings. We aimed to inform planning by assessing intrinsic capacity prevalence, by characterising the target group, and by validating the general approach-testing hypotheses that DIC was consistently associated with higher risks of incident dependence and death. METHODS AND FINDINGS: We conducted population-based cohort studies (baseline, 2003-2007) in urban sites in Cuba, Dominican Republic, Puerto Rico, and Venezuela, and rural and urban sites in Peru, Mexico, India, and China. Door-knocking identified eligible participants, aged 65 years and over and normally resident in each geographically defined catchment area. Sociodemographic, behaviour and lifestyle, health, and healthcare utilisation and cost questionnaires, and physical assessments were administered to all participants, with incident dependence and mortality ascertained 3 to 5 years later (2008-2010). In 12 sites in 8 countries, 17,031 participants were surveyed ...