Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence

作者：Stephan B. Dreyer, Rosanna Upstill‐Goddard, Assya Legrini, Andrew V. Biankin, Sarah Allison, Andrew V. Biankin, Dario Beraldi, Euan Cameron, David K. Chang, Susanna L. Cooke, Richard Cunningham, Stephan Dreyer, Paul Grimwood, Shane Kelly, John L. Marshall, Brian McDade, Elizabeth A. Musgrove, Donna Ramsay, Rosie Upstill-Goddard, Lisa Evers, Selma Rebus, Lola Rahib, Bryan Serrels, Nigel B. Jamieson, Colin J. McKay, Paul Westwood, Nicola Williams, Fraser R. Duthie, William Shen, Antonio Pea, Amber L. Johns, Anthony J. Gill, Lorraine A. Chantrill, Paul Timpson, Angela Chou, Marina Pajic, Tanya Dwarte, David Herrmann, Claire Vennin, Thomas R. Cox, Brooke Pereira, Shona Ritchiee, Daniel A. Reed, Cecilia R. Chambers, Xanthe L. Metcalf, Max Nobis, Gloria Jeong, Lara Kenyon, Ruth J. Lyons, Nicola Waddell, John V. Pearson, Ann‐Marie Patch, Kátia Nones, Felicity Newell, Pamela Mukhopadhyay, Venkateswar Addala, Stephen H. Kazakoff, Oliver Holmes, Conrad Leonard, Scott Wood, Sean M. Grimmond, Oliver Hofmann, Jaswinder S. Samra, Nick Pavlakis, Jennifer Arena, Hilda A. High, Ray Asghari, Neil D. Merrett, Amitabha Das, Peter H. Cosman, Kasim Ismail, Alina Stoita, David Williams, Allan Spigellman, Duncan McLeod, Judy Kirk, James G. Kench, Peter Grimison, Charbel Sandroussi, Annabel Goodwin, R. Scott Mead, Katherine Tucker, Lesley Andrews, Michael Texler, Cindy Forrest, Mo Ballal, David Fletcher, Maria Beilin, Kynan Feeney, Krishna Epari, Sanjay Mukhedkar, Nikolajs Zeps, Nan Q. Nguyen, Andrew Ruszkiewicz, Chris Worthley, John Chen, Mark E. Brooke‐Smith, Virginia Papangelis, Andrew D. Clouston, Andrew P. Barbour, Thomas J. O’Rourke, Jonathan W. Fawcett, Kellee Slater, Michael Hatzifotis, Peter Hodgkinson, Mehrdad Nikfarjam, James R. Eshleman, Ralph H. Hruban, Christopher L. Wolfgang, Aldo Scarpa, Rita T. Lawlor, Vincenzo Corbo, Claudio Bassi, Andrew V. Biankin, Nigel B. Jamieson, David K. Chang, Stephan B. Dreyer, Nigel B. Jamieson, David K. Chang, Nigel B. Jamieson, David K. Chang · 发表于：Gastroenterology · 年份：2021 · DOI：10.1053/j.gastro.2021.09.022 · 被引用次数：48 · 研究领域：Pancreatic and Hepatic Oncology Research、Cancer Genomics and Diagnostics、Epigenetics and DNA Methylation

Pancreatic cancer (PC) remains a highly lethal malignancy, and most patients with localized disease that undergo surgical resection still succumb to recurrent disease. Pattern of recurrence after pancreatectomy is heterogenous, with some studies illustrating that site of recurrence can be associated with prognosis.1 Another study suggested that tumors that develop local and distant recurrence can be regarded as a homogenous disease with similar outcomes.2 Here we investigate novel molecular determinants of recurrence pattern after pancreatectomy for PC.