Association between anion gap and mortality of aortic aneurysm in intensive care unit after open surgery

作者：Yijing Gao, Zilin Hong, Runnan Shen, Shiran Zhang, Guochang You, Jie Chen, Xushun Guo, Senyi Peng, Kai Huang · 发表于：BMC Cardiovascular Disorders · 年份：2021 · DOI：10.1186/s12872-021-02263-4 · 被引用次数：23 · 研究领域：Renal function and acid-base balance、Chemical and Physical Studies、Acute Kidney Injury Research

BACKGROUND: There has not been a well-accepted prognostic model to predict the mortality of aortic aneurysm patients in intensive care unit after open surgery repair. Otherwise, our previous study found that anion gap was a prognosis factor for aortic aneurysm patients. Therefore, we wanted to investigate the relationship between anion gap and mortality of aortic aneurysm patients in intensive care unit after open surgery repair. METHODS: From Medical Information Mart for Intensive Care III, data of aortic aneurysm patients in intensive care unit after open surgery were enrolled. The primary clinical outcome was defined as death in intensive care unit. Univariate analysis was conducted to compare the baseline data in different groups stratified by clinical outcome or by anion gap level. Restricted cubic spline was drawn to find out the association between anion gap level and mortality. Subgroup analysis was then conducted to show the association in different level and was presented as frost plot. Multivariate regression models were built based on anion gap and were adjusted by admission information, severity score, complication, operation and laboratory indicators. Receiver operating characteristic curves were drawn to compare the prognosis ability of anion gap and simplified acute physiology score II. Decision curve analysis was finally conducted to indicate the net benefit of the models. RESULTS: A total of 405 aortic aneurysm patients were enrolled in this study and the in...