The changing pattern of enteric pathogen infections in China during the COVID-19 pandemic: a nation-wide observational study

作者：Liping Wang, Jiayi Han, Shi-Xia Zhou, Linjie Yu, Qing‐Bin Lu, Xiao‐Ai Zhang, Xiao‐Ai Zhang, Xiang Ren, Cuihong Zhang, Yifei Wang, Sheng-Hong Lin, Qiang Xu, Bao‐Gui Jiang, Chen‐Long Lv, Jinjin Chen, Changjun Li, Zhongjie Li, Yang Yang, Wei Liu, Li‐Qun Fang, Simon I Hay, George F. Gao, Weizhong Yang · 发表于：The Lancet Regional Health - Western Pacific · 年份：2021 · DOI：10.1016/j.lanwpc.2021.100268 · 被引用次数：65 · 研究领域：Viral gastroenteritis research and epidemiology、SARS-CoV-2 detection and testing、Viral Infections and Immunology Research

Background Non pharmaceutical interventions (NPI) including hand washing directives were implemented in China and worldwide to combat the COVID-19 pandemic, which are likely to have had impacted a broad spectrum of enteric pathogen infections. Methods Etiologically diagnostic data from 45 937 and 67 395 patients with acute diarrhea between 2012 and 2020, who were tested for seven viral pathogens and 13 bacteria respectively, were analyzed to assess the changes of enteric pathogen infections in China during the first COVID-19 pandemic year compared to pre-pandemic years. Findings Test positive rates of all enteric viruses decreased during 2020, compared to the average levels during 2012−2019, with a relative decrease of 71•75% for adenovirus, 58•76% for norovirus, 53•50% for rotavirus A, and 72•07% for the combination of other four uncommon viruses. In general, a larger reduction of positive rate in viruses was seen among adults than pediatric patients. A rebound of rotavirus A was seen after September 2020 in North China rather than South China. Test positive rates of bacteria decreased during 2020, compared to the average levels during 2012−2019, excepting for nontyphoidal Salmonella and Campylobacter coli with 66•53% and 90•48% increase respectively. This increase was larger for pediatric patients than for adult patients. Interpretation The activity of enteric pathogens changed profoundly alongside the NPIs implemented during the COVID-19 pandemic in China. Greater reductio...