The SARS-CoV-2 B.1.618 variant slightly alters the spike RBD–ACE2 binding affinity and is an antibody escaping variant: a computational structural perspective

作者：Abbas Khan, Jianjun Gui, Waqar Ahmad, Inamul Haq, Marukh Shahid, Awais Ahmed Khan, Abdullah Shah, Arsala Khan, Liaqat Ali, Zeeshan Anwar, Muhammad Safdar, Jehad Abubaker, Nizam Uddin, Liqiang Cao, Dong‐Qing Wei, Anwar Mohammad · 发表于：RSC Advances · 年份：2021 · DOI：10.1039/d1ra04694b · 被引用次数：74 · 研究领域：SARS-CoV-2 and COVID-19 Research、Monoclonal and Polyclonal Antibodies Research、COVID-19 Clinical Research Studies

This study explored the binding patterns of the wild type and B.1.618 variant using which revealed that the B.1.618 variant possess a stronger binding affinity for the host ACE2 and escape the neutralizing antibodies.