Sex-specific phenotypic effects and evolutionary history of an ancient polymorphic deletion of the human growth hormone receptor

作者：Marie Saitou, Skyler Resendez, Apoorva J. Pradhan, Fuguo Wu, Natasha Lie, Nancy J. Hall, Qihui Zhu, Laura G. Reinholdt, Yoko Satta, Leo Speidel, Shigeki Nakagome, Neil A. Hanchard, Gary A. Churchill, Charles Lee, G. Ekin Atilla‐Gokcumen, Xiuqian Mu, Ömer Gökçümen · 发表于：Science Advances · 年份：2021 · DOI：10.1126/sciadv.abi4476 · 被引用次数：22 · 研究领域：Growth Hormone and Insulin-like Growth Factors、Diet and metabolism studies、Digestive system and related health

leads to the female-like gene expression in male livers and the disappearance of sexual dimorphism in weight. The sex- and diet-dependent effects of GHRd3 in our mouse model are consistent with a model in which the allele frequency of GHRd3 varies throughout human evolution as a response to fluctuations in resource availability.