Circular RNAs’ cap-independent translation protein and its roles in carcinomas

作者：Lian He, Changfeng Man, Shouyan Xiang, Lin Yao, Xiaoyan Wang, Yu Fan · 发表于：Molecular Cancer · 年份：2021 · DOI：10.1186/s12943-021-01417-4 · 被引用次数：103 · 研究领域：Circular RNAs in diseases、MicroRNA in disease regulation、RNA modifications and cancer

Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes. CircRNAs are involved in a variety of physiological and pathological processes, but their regulatory mechanisms are not fully understood. Given the development of the RNA deep-sequencing technology and the improvement of algorithms, some CircRNAs are discovered to encode proteins through the cap-independent mechanism and participate in the important process of tumorigenesis and development. Based on an overview of CircRNAs, this paper summarizes its translation mechanism and research methods, and reviews the research progress of CircRNAs translation in the field of oncology in recent years. Moreover, this paper aims to provide new ideas for tumor diagnosis and treatment through CircRNAs translation.