The Level and Significance of Circulating Angiotensin-III in Patients with Coronary Atherosclerosis

作者：Guoqing Yao, Wenjing Li, Wenzhao Liu, Jing-bo Xing, Cheng Zhang · 发表于：Journal of the Renin-Angiotensin-Aldosterone System · 年份：2021 · DOI：10.1155/2021/1704762 · 被引用次数：5 · 研究领域：Renin-Angiotensin System Studies、Protein Hydrolysis and Bioactive Peptides、Galectins and Cancer Biology

Objective. Angiotensin-III (Ang-III) is the downstream product of angiotensin-II (Ang-II) metabolized by aminopeptidase A (APA). At present, the research of Ang-III mainly concentrates on hypertension and the central renin-angiotensin system (RAS). However, few studies have focused on the relationship between Ang-III and coronary atherosclerosis (CAS). Methods and Results. Plasma Ang-III and APA levels were measured by the enzyme-linked immunosorbent assay (ELISA) in 44 normal subjects and 84 patients confirmed as having CAS by coronary angiography. Circulating Ang-III levels were significantly lower in patients with CAS than in normal controls ([Formula: see text]). APA levels were slightly lower in the CAS group ([Formula: see text]). According to the severity of atherosclerosis, CAS patients were divided into two groups. Compared with the controls, the APA and Ang-III levels were lower in the high scoring group and APA decreased significantly. Conclusions. Circulating Ang-III levels were reduced in patients with CAS, and the possible reason may be related to the decrease in the APA level.