Mental and neurological disorders and risk of COVID-19 susceptibility, illness severity and mortality: A systematic review, meta-analysis and call for action

作者：Lin Liu, Shuyu Ni, Wei Yan, Qing-Dong Lu, Yimiao Zhao, Yingying Xu, Huan Mei, Le Shi, Kai Yuan, Ying Han, Jiahui Deng, Yankun Sun, Shiqiu Meng, Zhengdong Jiang, Na Zeng, Jianyu Que, Yongbo Zheng, Bei-Ni Yang, Yi-Miao Gong, Arun Ravindran, Thomas R. Kosten, Yun Kwok Wing, Xiangdong Tang, Junliang Yuan, Ping Wu, Jie Shi, Yanping Bao, Lin Lü · 发表于：EClinicalMedicine · 年份：2021 · DOI：10.1016/j.eclinm.2021.101111 · 被引用次数：138 · 研究领域：Long-Term Effects of COVID-19、Pharmacological Receptor Mechanisms and Effects、COVID-19 and Mental Health

BACKGROUND: Coronavirus disease 2019 (COVID-19) has evolved into a worldwide pandemic, and has been found to be closely associated with mental and neurological disorders. We aimed to comprehensively quantify the association between mental and neurological disorders, both pre-existing and subsequent, and the risk of susceptibility, severity and mortality of COVID-19. METHODS: heterogeneity, we used a random effects model to calculate pooled odds ratios (OR) and 95% confidence intervals (95% CI). Subgroup analyses and meta-regression analysis were also performed. This study was registered on PROSPERO (registration number: CRD 42021230832). FINDING: A total of 149 studies (227,351,954 participants, 89,235,737 COVID-19 patients) were included in this analysis, in which 27 reported morbidity (132,727,798), 56 reported illness severity (83,097,968) and 115 reported mortality (88,878,662). Overall, mental and neurological disorders were associated with a significant high risk of infection (pre-existing mental: OR 1·67, 95% CI 1·12-2·49; and pre-existing neurological: 2·05, 1·58-2·67), illness severity (mental: pre-existing, 1·40, 1·25-1·57; sequelae, 4·85, 2·53-9·32; neurological: pre-existing, 1·43, 1·09-1·88; sequelae, 2·17, 1·45-3·24), and mortality (mental: pre-existing, 1·47, 1·26-1·72; neurological: pre-existing, 2·08, 1·61-2·69; sequelae, 2·03, 1·66-2·49) from COVID-19. Subgroup analysis revealed that association with illness severity was stronger among younger COVID-19 patie...