Prenatal and postnatal exposure to PFAS and cardiometabolic factors and inflammation status in children from six European cohorts

作者：Eleni Papadopoulou, Nikos Stratakis, Xavier Basagaña, Anne Lise Brantsæter, Maribel Casas, Serena Fossati, Regina Gražulevičienė, Line Småstuen Haug, Barbara Heude, Léa Maître, Rosemary McEachan, Oliver Robinson, Theano Roumeliotaki, Eduard Sabidó, Eva Borràs, José Urquiza, Marina Vafeiadi, Yinqi Zhao, Rémy Slama, John Wright, David V. Conti, Martine Vrijheid, Lida Chatzi · 发表于：Environment International · 年份：2021 · DOI：10.1016/j.envint.2021.106853 · 被引用次数：98 · 研究领域：Health, Environment, Cognitive Aging、Birth, Development, and Health、Per- and polyfluoroalkyl substances research

Developing children are particularly vulnerable to the effects of exposure to per- and polyfluoroalkyl substances (PFAS), a group of endocrine disrupting chemicals. We hypothesized that early life exposure to PFASs is associated with poor metabolic health in children. We studied the association between prenatal and postnatal PFASs mixture exposure and cardiometabolic health in children, and the role of inflammatory proteins. In 1,101 mothers-child pairs from the Human Early Life Exposome project, we measured the concentrations of PFAS in blood collected in pregnancy and at 8 years (range = 6-12 years). We applied Bayesian Kernel Machine regression (BKMR) to estimate the associations between exposure to PFAS mixture and the cardiometabolic factors as age and sex- specific z-scores of waist circumference (WC), systolic and diastolic blood pressures (BP), and concentrations of triglycerides (TG), high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) cholesterol. We measured thirty six inflammatory biomarkers in child plasma and examined the underlying role of inflammatory status for the exposure-outcome association by integrating the three panels into a network. Exposure to the PFAS mixture was positively associated with HDL-C and systolic BP, and negatively associated with WC, LDL-C and TG. When we examined the independent effects of the individual chemicals in the mixture, prenatal PFHxS was negatively associated with HDL-C and prenatal PFNA was positively assoc...