Plasma Levels of the Cytokines B Cell-Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) in Schizophrenia, Bipolar, and Major Depressive Disorder: A Cross Sectional, Multisite Study

作者：John Abel Engh, Thor Ueland, Ingrid Agartz, Dimitrios Andreou, Pål Aukrust, Birgitte Boye, Erlend Bøen, Ole Kristian Drange, Torbjørn Elvsåshagen, Sigrun Hope, Margrethe Collier Høegh, Inge Joa, Erik Johnsen, Rune A. Kroken, Trine Vik Lagerberg, Tove Lekva, Ulrik Fredrik Malt, Ingrid Melle, Gunnar Morken, Terje Nærland, Vidar M. Steen, Kirsten Wedervang‐Resell, Melissa Auten Weibell, Lars T. Westlye, Srdjan Djurovic, Nils Eiel Steen, Ole A. Andreassen · 发表于：Schizophrenia Bulletin · 年份：2021 · DOI：10.1093/schbul/sbab106 · 被引用次数：27 · 研究领域：Tryptophan and brain disorders、Schizophrenia research and treatment、Bipolar Disorder and Treatment

BACKGROUND: Immune dysfunction has been implicated in the pathogenesis of schizophrenia and other nonaffective psychosis (SCZ), bipolar spectrum disorder (BIP) and major depressive disorder (MDD). The cytokines B cell-activating factor (BAFF) and A proliferation-inducing ligand (APRIL) belong to the tumor necrosis factor (TNF) super family and are essential in orchestrating immune responses. Abnormal levels of BAFF and APRIL have been found in autoimmune diseases with CNS affection. METHODS: We investigated if plasma levels of BAFF and APRIL differed between patients with SCZ, BIP, and MDD with psychotic symptoms (n = 2009) and healthy control subjects (HC, n = 1212), and tested for associations with psychotic symptom load, controlling for sociodemographic status, antipsychotic and other psychotropic medication, smoking, body-mass-index, and high sensitivity CRP. RESULTS: Plasma APRIL level was significantly lower across all patient groups compared to HC (P < .001; Cohen's d = 0.33), and in SCZ compared to HC (P < .001; d = 0.28) and in BIP compared to HC (P < .001; d = 0.37). Lower plasma APRIL was associated with higher psychotic symptom load with nominal significance (P = .017), but not with any other clinical characteristics. Plasma BAFF was not significantly different across patient groups vs HC, but significantly higher in BIP compared to HC (P = .040; d = 0.12) and SCZ (P = .027; d = 0.10). CONCLUSIONS: These results show aberrant levels of BAFF and APRIL and associati...