Europium Doped Silicon Quantum Dot As a Novel FRET Based Dual Detection Probe: Sensitive Detection of Tetracycline, Zinc, and Cadmium

作者：Jialing Zhou, Ruoxi Zhao, Shi-Kai Liu, Lili Feng, Wenting Li, Fei He, Shili Gai, Piaoping Yang · 发表于：Small Methods · 年份：2021 · DOI：10.1002/smtd.202100812 · 被引用次数：59 · 研究领域：Carbon and Quantum Dots Applications、Advanced biosensing and bioanalysis techniques、Biosensors and Analytical Detection

Abstract The imbalance of Zn2+/Cd2+ in the human body can lead to many serious diseases due to the overuse of antibiotics and deposition in animal products. Developing a functional material for detecting is challenging and in demand. Herein, silicon quantum dots (SiQDs) are designed as a functional platform for the detection of tetracycline and Zn2+/Cd2+. The COOH functionalized SiQDs with the emission wavelength of 450 nm are chelated with Eu(NO3)3 to form SiQDs‐Eu3+ ratio fluorescent probes, which can be used to detect tetracycline (TCs) and Zn2+/Cd2+ by fluorescence resonance energy transfer (FRET) principle sequentially. The fluorescent probe showed good linearity between ion concentration and fluorescence enhancement. The detection limit of TCs and Zn2+/Cd2+ are 0.2 × 10−6 m and 3 × 10−6 m, respectively, when the pH of the solution is 7.4. In addition, the synthesized SiQDs‐Eu3+ exhibited good stability (from 94.9% to 103.1%). The relative standard deviations (RSD, n = 10) of human serum and urine were both less than 3%. Therefore, the SiQDs‐Eu3+ ratio fluorescence probe will provide a good application prospect in actual sample detection.