The effectiveness of pre- and post-operative rehabilitation for lung cancer: A systematic review and meta-analysis on postoperative pulmonary complications and length of hospital stay

作者：Xinyi Xu, Denise Shuk Ting Cheung, Robert David Smith, Agnes Yuen Kwan Lai, Chia‐Chin Lin · 发表于：Clinical Rehabilitation · 年份：2021 · DOI：10.1177/02692155211043267 · 被引用次数：42 · 研究领域：Lung Cancer Diagnosis and Treatment、Cancer survivorship and care、Enhanced Recovery After Surgery

Objective: To investigate the effects of rehabilitation either before or after operation for lung cancer on postoperative pulmonary complications and the length of hospital stay. Data sources: MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, CINAHL Plus, SPORTDiscus, PsycInfo and Embase were searched from inception until June 2021. Review methods: Inclusion criteria were patients scheduled to undergo or had undergone operation for lung cancer, randomised controlled trials comparing rehabilitative interventions initiated before hospital discharge to usual care control. Two reviewers independently assessed eligibility, extracted data and risks of bias. Pooled odds ratios (ORs) or standardised mean differences (SMDs) with 95% Confidence Intervals (CI) were estimated using random-effects meta-analyses. Results: Twenty-three studies were included (12 preoperative, 10 postoperative and 1 perioperative), with 2068 participants. The pooled postoperative pulmonary complication risk and length of hospital stay were reduced after preoperative interventions (OR = 0.32; 95% CI = 0.22, 0.47; I 2 = 0.0% and SMD = −1.68 days, 95% CI = −2.23, −1.13; I 2 = 77.8%, respectively). Interventions delivered during the immediate postoperative period did not have any significant effects on either postoperative pulmonary complication or length of hospital stay (OR = 0.85; 95% CI = 0.56, 1.29; I 2 = 0.0% and SMD = −0.23 days, 95% CI = −1.08, 0.63; I 2 = 64.6%, respectively). Meta...