Arachidonic Acid 15-Lipoxygenase: Effects of Its Expression, Metabolites, and Genetic and Epigenetic Variations on Airway Inflammation

作者：Xu Xu, Jingyun Li, Yuan Zhang, Luo Zhang · 发表于：Allergy Asthma and Immunology Research · 年份：2021 · DOI：10.4168/aair.2021.13.5.684 · 被引用次数：77 · 研究领域：Asthma and respiratory diseases、Pediatric health and respiratory diseases、Genomics, phytochemicals, and oxidative stress

gene, such as DNA methylation and histone modifications, have been shown to closely relate with airway inflammation. This review summarizes the role of ALOX15 in different phenotypes of asthma, chronic obstructive pulmonary disease, chronic rhinosinusitis, aspirin-exacerbated respiratory disease, and nasal polyps, suggesting new treatment strategies for these airway inflammatory diseases with complex etiology and poor treatment response.