Enhanced Virus Detection and Metagenomic Sequencing in Patients with Meningitis and Encephalitis

作者：Anne Piantadosi, Shibani S. Mukerji, Simon Ye, Michael J. Leone, Lisa M. Freimark, Daniel Park, Gordon Adams, Jacob E. Lemieux, Sanjat Kanjilal, Isaac H. Solomon, Asim Ahmed, Robert H. Goldstein, Vijay Ganesh, Bridget Ostrem, Kaelyn C. Cummins, Jesse Thon, Cormac M. Kinsella, Eric Rosenberg, Matthew P. Frosch, Marcia B. Goldberg, Tracey Cho, Pardis Sabeti · 发表于：mBio · 年份：2021 · DOI：10.1128/mbio.01143-21 · 被引用次数：125 · 研究领域：Respiratory viral infections research、Virology and Viral Diseases、Viral Infections and Immunology Research

= 24) CNS viral infection from a single center in New England and evaluated enhanced methods to improve the detection of CNS pathogens, including those not traditionally identified in the CNS by nucleic acid detection. Overall, our work helps elucidate how mNGS can become integrated into the diagnostic toolkit for CNS infections.