Clinical Characteristics and Outcomes of Hypertensive Patients Infected with COVID-19: A Retrospective Study

作者：Liqin Chen, Jiankun Chen, Yuwan Wu, Jinyao Zhong, Fu-zhen Zhou, Yuntao Liu, Aiting Xu, Jiqiang Li, Huayang Cai · 发表于：International Journal of General Medicine · 年份：2021 · DOI：10.2147/ijgm.s324077 · 被引用次数：4 · 研究领域：COVID-19 Clinical Research Studies、Long-Term Effects of COVID-19、Dermatological and COVID-19 studies

BACKGROUND: Hypertension has been reported as the most prevalent comorbidity in patients with coronavirus disease 2019 (COVID-19). This retrospective study aims to compare the clinical characteristics and outcomes in COVID-19 patients with or without hypertension. METHODS: A total of 944 hospitalized patients with laboratory-confirmed COVID-19 were included from January to March 2020. Information from the medical record, including clinical features, radiographic and laboratory results, complications, treatments, and clinical outcomes, were extracted for the analysis. RESULTS: A total of 311 (32.94%) patients had comorbidity with hypertension. In COVID-19 patients with hypertension, the coexistence of type 2 diabetes (56.06% vs 43.94%), coronary heart disease (65.71% vs 34.29%), poststroke syndrome (68.75% vs 31.25%) and chronic kidney diseases (77.78% vs 22.22%) was significantly higher, while the coexistence of hepatitis B infection (13.04% vs 86.96%) was significantly lower than in COVID-19 patients without hypertension. Computed tomography (CT) chest scans show that COVID-19 patients with hypertension have higher rates of pleural effusion than those without hypertension (56.60% vs 43.40%). In addition, the levels of blood glucose [5.80 (IQR, 5.05-7.50) vs 5.39 (IQR, 4.81-6.60)], erythrocyte sedimentation rate (ESR) [28 (IQR, 17.1-55.6) vs 21.8 (IQR, 11.5-44.1), P=0.008], C-reactive protein (CRP) [17.92 (IQR, 3.11-46.6) vs 3.15 (IQR, 3.11-23.4), P=0.013] and serum amyloid A...