Examining the interseasonal resurgence of respiratory syncytial virus in Western Australia

作者：David A. Foley, Linny Kimly Phuong, Joseph Peplinski, Selina Lim, Wei Hao Lee, Asifa Farhat, Cara Minney‐Smith, Andrew C. Martin, Ariel O Mace, Chisha Sikazwe, Huong Le, Avram Levy, Tobias Hoeppner, Meredith L Borland, Briony Hazelton, Hannah C. Moore, Christopher C. Blyth, Daniel K. Yeoh, Asha C Bowen · 发表于：Archives of Disease in Childhood · 年份：2021 · DOI：10.1136/archdischild-2021-322507 · 被引用次数：141 · 研究领域：Respiratory viral infections research、COVID-19 Clinical Research Studies、Cystic Fibrosis Research Advances

BACKGROUND: Following a relative absence in winter 2020, a large resurgence of respiratory syncytial virus (RSV) detections occurred during the 2020/2021 summer in Western Australia. This seasonal shift was linked to SARS-CoV-2 public health measures. We examine the epidemiology and RSV testing of respiratory-coded admissions, and compare clinical phenotype of RSV-positive admissions between 2019 and 2020. METHOD: At a single tertiary paediatric centre, International Classification of Diseases, 10th edition Australian Modification-coded respiratory admissions longer than 12 hours were combined with laboratory data from 1 January 2019 to 31 December 2020. Data were grouped into bronchiolitis, other acute lower respiratory infection (OALRI) and wheeze, to assess RSV testing practices. For RSV-positive admissions, demographics and clinical features were compared between 2019 and 2020. RESULTS: RSV-positive admissions peaked in early summer 2020, following an absent winter season. Testing was higher in 2020: bronchiolitis, 94.8% vs 89.2% (p=0.01); OALRI, 88.6% vs 82.6% (p=0.02); and wheeze, 62.8% vs 25.5% (p<0.001). The 2020 peak month, December, contributed almost 75% of RSV-positive admissions, 2.5 times the 2019 peak. The median age in 2020 was twice that observed in 2019 (16.4 vs 8.1 months, p<0.001). The proportion of RSV-positive OALRI admissions was greater in 2020 (32.6% vs 24.9%, p=0.01). There were no clinically meaningful differences in length of stay or disease severi...