Nanostructured Phthalocyanine Assemblies with Efficient Synergistic Effect of Type I Photoreaction and Photothermal Action to Overcome Tumor Hypoxia in Photodynamic Therapy

作者：Yuanyuan Zhao, Ling Zhang, Zixuan Chen, Biyuan Zheng, Mei‐Rong Ke, Xingshu Li, Jian‐Dong Huang · 发表于：Journal of the American Chemical Society · 年份：2021 · DOI：10.1021/jacs.1c07479 · 被引用次数：241 · 研究领域：Nanoplatforms for cancer theranostics、Photodynamic Therapy Research Studies、Luminescence and Fluorescent Materials

Most photodynamic therapy (PDT) paradigms work through the highly O 2 -dependent type II photoreaction to generate singlet oxygen ( 1 O 2 ). The hypoxic microenvironment of solid tumors severely hampers therapeutic outcomes. Here, we present a novel design that could transfer the photophysical and photochemical properties of traditional phthalocyanine-based photosensitizers from type II photoreaction to efficient type I photoreaction and vibrational relaxation-induced photothermal conversion. These features enable the obtained nanostructured phthalocyanine assemblies (e.g., NanoPcAF) to display excellent phototherapies under both normoxic and hypoxic conditions. Moreover, NanoPcAF has a high level of accumulation in tumor tissues after intravenous injection, and 94% of tumor growth is inhibited in a preclinical model at a NanoPcAF dose of 0.8 nmol g –1 and light dose of 300 J cm –2 .