Circulating retinol binding protein 4 levels in coronary artery disease: a systematic review and meta-analysis

作者：Hengying Chen, Jiaying Zhang, Jiayu Lai, Yingyu Zhou, Xiaoping Lin, Guifang Deng, Zheqing Zhang, Liping Li · 发表于：Lipids in Health and Disease · 年份：2021 · DOI：10.1186/s12944-021-01516-7 · 被引用次数：8 · 研究领域：Retinoids in leukemia and cellular processes、Antioxidant Activity and Oxidative Stress、Cardiovascular Disease and Adiposity

Abstract Background Retinol binding protein 4 (RBP4) has been proposed to play a role in the pathophysiology of coronary artery disease (CAD), but previous findings on the association of RBP4 levels with CAD are inconsistent. Methods A meta-analysis based on observational studies was conducted to evaluate the association between circulating RBP4 levels and CAD. Databases including PubMed, Web of Science, Embase, Google Scholar and ClinicalTrials.gov database were searched for eligible studies published up to 12 July 2021. Standard mean differences (SMDs) with 95% confidence intervals (CIs) were calculated using the inverse variance heterogeneity (IVhet) and random-effects model for data with moderate and high heterogeneity ( I 2 > 30%) and data with low heterogeneity were analysed using a fixed-effects model ( I 2 ≤ 30%). Moreover, a bias-adjusted quality-effects model was generated, and the prediction interval was also calculated under the random-effects model. Results Two nested case-control studies, one cohort study and twelve case–control studies with a total of 7111 participants were included. Circulating RBP4 levels in patients with CAD were comparable to those in the controls under the IVhet model (SMD: 0.25, 95% CI: − 0.29-0.79, I 2 : 96.00%). The quality-effects model produced consistent results. However, the association turned to be significant under the random-effect model (SMD: 0.46, 95% CI: 0.17–0.75, I 2 : 96.00%), whereas the 95% predictive interval (PI) inc...