The association between effectiveness of first-line treatment and second-line treatment in gastro-oesophageal cancer

作者：M.J.M. van Velzen, Marieke Pape, Willemieke P.M. Dijksterhuis, Marije Slingerland, Theo van Voorthuizen, Laurens Victor Beerepoot, Geert-Jan M. Creemers, Sarah Derks, Nadia Haj Mohammad, Rob H.A. Verhoeven, Hanneke W. M. van Laarhoven · 发表于：European Journal of Cancer · 年份：2021 · DOI：10.1016/j.ejca.2021.07.026 · 被引用次数：8 · 研究领域：Esophageal Cancer Research and Treatment、Gastric Cancer Management and Outcomes、Colorectal Cancer Surgical Treatments

BACKGROUND: Population-based predictive factors for the effectiveness of second-line palliative systemic therapy in gastro-oesophageal cancer are not available. This study investigates the predictive value of effectiveness of first-line treatment for second-line treatment outcomes in gastro-oesophageal cancer in a real-world setting. METHODS: Patients with metastatic gastro-oesophageal cancer diagnosed in 2010-2017 who were treated with second-line therapy after disease progression on first-line therapy were identified from the Netherlands Cancer Registry. Patients were divided into four groups as per duration of time to treatment failure (TTF) of the first line (0-3, 3-6, 6-9 and >9 months), and the association with overall survival (OS) and second-line TTF was assessed using Kaplan-Meier curves and two-sided multivariable regression models. RESULTS: Median OS since the start of the second line of patients (n = 611) with first-line TTF of 0-3, 3-6, 6-9 and >9 months was 4.0, 4.1, 5.5 and 7.1 months, respectively (P < 0.001). Median second-line TTF of patients with first-line TTF of 0-3, 3-6, 6-9 and >9 months was 2.8, 2.4, 3.0 and 4.5 months, respectively (P < 0.001). Patients with first-line TTF of >9 months showed a longer OS than patients with first-line TTF of 0-3 months (adjusted hazard ratio (HR) 1.90; 95% confidence interval (CI) 1.46-2.47), 3-6 months (adjusted HR 1.88; 95% CI 1.47-2.39) and 6-9 months (adjusted HR 1.31; 95% CI 1.04-1.65). Results for second-line TTF...