cGAS-STING Signaling Pathway and Liver Disease: From Basic Research to Clinical Practice

作者：Bangjie Chen, Xianyue Rao, Xinyi Wang, Zhipan Luo, Jianpeng Wang, Shuyan Sheng, Yuchen Liu, Ning Zhang, Shiyu Jin, Haosong Chen, Chenyu Sun, Tao Xu, Yingying Du · 发表于：Frontiers in Pharmacology · 年份：2021 · DOI：10.3389/fphar.2021.719644 · 被引用次数：41 · 研究领域：interferon and immune responses、Viral Infections and Vectors、Inflammasome and immune disorders

The cGAS-STING signaling pathway is an autoimmune inflammatory pathway that can trigger the expression of a series of inflammatory factors represented by type 1 interferon. Recent studies have found that the cGAS-STING signaling pathway played a significant role in liver physiology and was closely related to the progress of liver diseases. For example, activating the cGAS-STING signaling pathway could significantly inhibit hepatitis B virus (HBV) replication in vivo. Moreover, the cGAS-STING signaling pathway was also closely associated with tumor immunity in hepatocellular carcinoma (HCC). This review summarized the role of the cGAS-STING signaling pathway in several common liver diseases, especially the current application of the cGAS-STING signaling pathway in liver disease treatment, and prospected its future research, which provided a new idea for understanding and treating liver diseases.