Comparative Genomics Reveals a Remarkable Biosynthetic Potential of the Streptomyces Phylogenetic Lineage Associated with Rugose-Ornamented Spores

作者：Yoon‐Hee Chung, Hiyoung Kim, Chang-Hun Ji, Hyun-Woo Je, Dongho Lee, Sang Hee Shim, Hwang‐Soo Joo, Hahk‐Soo Kang · 发表于：mSystems · 年份：2021 · DOI：10.1128/msystems.00489-21 · 被引用次数：37 · 研究领域：Microbial Natural Products and Biosynthesis、Genomics and Phylogenetic Studies、RNA and protein synthesis mechanisms

phylogeny, we identified a specific monophyletic lineage associated with the highest BGC abundance. Then, using a combined analysis of comparative genomics and a genetic network, we demonstrated that members of this lineage are genetically and biosynthetically diverse, contain a large number of cryptic BGCs with novel genotypes, and thus would be a good target for metabolite characterization studies.