Mitochondrial Fusion Mediated by Mitofusin 1 Regulates Macrophage Mycobactericidal Activity by Enhancing Autophagy

作者：Yuping Ning, Yi Cai, Youchao Dai, Fuxiang Li, Siwei Mo, Oliver Werz, Xinchun Chen · 发表于：Infection and Immunity · 年份：2021 · DOI：10.1128/iai.00306-21 · 被引用次数：23 · 研究领域：Autophagy in Disease and Therapy、Mitochondrial Function and Pathology、ATP Synthase and ATPases Research

inhibited mitochondrial fusion and subsequently reduced ATP production, which, in turn, severely impaired macrophages' mycobactericidal activity by inhibiting autophagy. Impairment of mycobactericidal activity and autophagy was replicated using oligomycin, an inhibitor of ATP synthase. In summary, our study revealed that MFN1-mediated mitochondrial fusion is essential for macrophages' mycobactericidal activity through the regulation of ATP-dependent autophagy. The MFN1-mediated metabolism pathway might be a target for the development of a host direct therapy (HDT) strategy against tuberculosis.