Catalytic Enantioselective Halocyclizations to Access Benzoxazepinones and Benzoxazecinones

作者：Xiaojian Jiang, Xi Xu, Wei Xu, Pei Yu, Ying‐Yeung Yeung · 发表于：Organic Letters · 年份：2021 · DOI：10.1021/acs.orglett.1c02117 · 被引用次数：18 · 研究领域：Vanadium and Halogenation Chemistry、Chemical Synthesis and Reactions、Oxidative Organic Chemistry Reactions

We report a catalytic asymmetric halocyclization protocol to furnish benzoxazepinones and benzoxazecinones using (DHQ) 2 PHAL as the catalyst. Various halogenated benzoxazepinones and benzoxazecinones were achieved in excellent yields and enantioselectivities under mild conditions. A cocrystal structure of the substrate and the catalyst was studied.