Extreme laryngeal candidiasis: airway obstruction

作者：Susan C Murray, C. Thompson, David Walker, Miles Bannister · 发表于：BMJ Case Reports · 年份：2021 · DOI：10.1136/bcr-2021-242910 · 被引用次数：3 · 研究领域：Antifungal resistance and susceptibility、Respiratory and Cough-Related Research、Fungal Infections and Studies

We describe the case of a 33-year-old female smoker who presented to the Accident and Emergency department with a 1-day history of rapidly evolving airway compromise. She had no preceding illness or other objective signs/symptoms on presentation, had a history of Chronic Obstructive Pulmonary Disease (COPD) and a previous opioid addiction. Following failed endotracheal intubation, the airway was secured with an emergency surgical tracheostomy. Subsequent direct laryngoscopy revealed a severely diseased glottis and supraglottic area, from which biopsy samples revealed a multiple drug-resistant strain of Candida albicans requiring specialist microbiology input and antifungal treatment. We describe the presentation, investigation, management and outcome of this rare case, along with a literature review of the subject.