First pregnancy in China after ovarian tissue transplantation to prevent premature ovarian insufficiency

作者：Xiangyan Ruan, Juan Du, Dan Lu, W. Duan, Fang Jin, Wei­min Kong, Ying Wu, Yinmei Dai, Shengtao Yan, Chenghong Yin, Y. Li, Jiumei Cheng, Cuiyu Jia, X. Liu, Qingqing Wu, Meng Gu, R. Ju, Xiyuan Xu, Yingchi Yang, Jiayan Jin, M. Korell, Markus Montag, Jana Liebenthron, A. O. Mueck · 发表于：Climacteric · 年份：2021 · DOI：10.1080/13697137.2021.1956453 · 被引用次数：12 · 研究领域：Reproductive Biology and Fertility、Cancer Risks and Factors、Reproductive System and Pregnancy

OBJECTIVE: This article reports the first case of pregnancy after frozen-thawed ovarian tissue transplantation to prevent iatrogenic premature ovarian insufficiency in China. METHODS: Ovarian tissue cryopreservation was performed in a patient with myelodysplastic syndrome (MDS) before multi-agent chemotherapy and hematopoietic stem cell transplantation. Two years later, she showed complete remission from MDS, and six frozen-thawed ovarian tissue strips were transplanted into the peritoneal pocket. RESULTS: The patient's ovarian activity was restored 3 months after transplantation, and pregnancy occurred spontaneously 27 months after grafting. Until now, the pregnancy has progressed for 30 weeks, and the repeated ultrasound showed normal fetal development. CONCLUSION: This is the first pregnancy resulting from ovarian tissue cryopreservation and transplantation in China.