Epidemiology and microbiology of fracture-related infection: a multicenter study in Northeast China

作者：Baisheng Wang, Xiaoguang Xiao, Jingdong Zhang, Wenfeng Han, Salad Abdirahman Hersi, Xin Tang · 发表于：Journal of Orthopaedic Surgery and Research · 年份：2021 · DOI：10.1186/s13018-021-02629-6 · 被引用次数：54 · 研究领域：Orthopedic Infections and Treatments、Surgical site infection prevention、Antimicrobial Resistance in Staphylococcus

OBJECTIVE: This study aimed to explore the epidemiological and microbiological characteristics of fracture-related infection (FRI), analyze the drug resistance characteristics of major pathogens, and provide timely and relatively complete clinical and microbiological data for antimicrobial treatment of FRI. METHODS: The clinical and microbiological data of patients with FRI from January 1, 2011, to December 31, 2020, were collected from three tertiary hospitals in Northeast China. The automatic microbial analysis system was used for strain identification and drug susceptibility testing, and the drug susceptibility results were determined in accordance with the latest Clinical and Laboratory Standards Institute (CLSI) criteria (as applicable each year). RESULTS: A total of 744 patients with FRI were enrolled. The incidence of FRI was about 1.5%, and 81.7% were male patients, with an average age of 48.98 ± 16.01 years. Open fractures accounted for 64.8%. Motor crush (32.8%) and falling (29.8%) were the main causes of injuries. The common sites of infection were the tibia and fibula (47.6%), femur (11.8%), foot (11.8%), and hand (11.6%). A total of 566 pathogenic bacteria were cultured in 378 patients with positive bacterial cultures, of which 53.0% were Gram-positive bacteria and 47.0% were Gram-negative bacteria. The most common pathogen at all sites of infection is Staphylococcus aureus. Staphylococcus aureus had a high resistance rate to penicillin (PEN), erythromycin (ERY),...