Relationship Between Amyloid-β Deposition and Blood–Brain Barrier Dysfunction in Alzheimer’s Disease

作者：Dong Wang, Fanglian Chen, Zhaoli Han, Zhenyu Yin, Xintong Ge, Ping Lei · 发表于：Frontiers in Cellular Neuroscience · 年份：2021 · DOI：10.3389/fncel.2021.695479 · 被引用次数：196 · 研究领域：Alzheimer's disease research and treatments、Drug Transport and Resistance Mechanisms、Cholinesterase and Neurodegenerative Diseases

Amyloid-β (Aβ) is the predominant pathologic protein in Alzheimer's disease (AD). The production and deposition of Aβ are important factors affecting AD progression and prognosis. The deposition of neurotoxic Aβ contributes to damage of the blood-brain barrier. However, the BBB is also crucial in maintaining the normal metabolism of Aβ, and dysfunction of the BBB aggravates Aβ deposition. This review characterizes Aβ deposition and BBB damage in AD, summarizes their interactions, and details their respective mechanisms.